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JNJ 39758979
CAS No. 1046447-90-8
JNJ 39758979 ( JNJ-39758979;JNJ39758979 )
Catalog No. M10231 CAS No. 1046447-90-8
A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 178 | Get Quote |
|
| 10MG | 288 | Get Quote |
|
| 25MG | 484 | Get Quote |
|
| 50MG | 701 | Get Quote |
|
| 100MG | 981 | Get Quote |
|
| 500MG | 1962 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJNJ 39758979
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.
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DescriptionA potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.Asthma Phase 2 Clinical
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SynonymsJNJ-39758979;JNJ39758979
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number1046447-90-8
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Formula Weight221.31
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Molecular FormulaC11H19N5
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Purity>98% (HPLC)
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SolubilityDMSO : 33.33 mg/mL 150.61 mM;
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SMILESNC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1
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Chemical Name(R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Savall BM, et al. J Med Chem. 2014 Mar 27;57(6):2429-39.
2. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84.
3. Kollmeier A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7.
4. Murata Y, et al. J Dermatol. 2015 Feb;42(2):129-39.
2. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84.
3. Kollmeier A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7.
4. Murata Y, et al. J Dermatol. 2015 Feb;42(2):129-39.
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