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Home - Products - GPCR/G Protein - Histamine Receptor - JNJ 39758979

JNJ 39758979

CAS No. 1046447-90-8

JNJ 39758979 ( JNJ-39758979;JNJ39758979 )

Catalog No. M10231 CAS No. 1046447-90-8

A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNJ 39758979
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.
  • Description
    A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.Asthma Phase 2 Clinical
  • Synonyms
    JNJ-39758979;JNJ39758979
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    1046447-90-8
  • Formula Weight
    221.31
  • Molecular Formula
    C11H19N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 33.33 mg/mL 150.61 mM;
  • SMILES
    NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1
  • Chemical Name
    (R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Savall BM, et al. J Med Chem. 2014 Mar 27;57(6):2429-39.
2. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84.
3. Kollmeier A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7.
4. Murata Y, et al. J Dermatol. 2015 Feb;42(2):129-39.
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