JNJ 39758979 ( JNJ-39758979;JNJ39758979 )

Catalog No. M10231 CAS No. 1046447-90-8

A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
5MG	178	Get Quote
10MG	288	Get Quote
25MG	484	Get Quote
50MG	701	Get Quote
100MG	981	Get Quote
500MG	1962	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

JNJ 39758979
Note

Research use only, not for human use.
Brief Description

A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM.
Description

A potent, selective, orally bioavailable histamine H4 receptor antagonist with Ki of 12.5 nM, >80-fold selectivity over other histamine receptors; shows dose-dependent activity in models of asthma and dermatitis, has good pharmacokinetics.Asthma Phase 2 Clinical
Synonyms

JNJ-39758979;JNJ39758979
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

Inflammation/Immunology
Indication

Asthma

Chemical Information

CAS Number

1046447-90-8
Formula Weight

221.31
Molecular Formula

C11H19N5
Purity

>98% (HPLC)
Solubility

DMSO : 33.33 mg/mL 150.61 mM;
SMILES

NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1
Chemical Name

(R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Savall BM, et al. J Med Chem. 2014 Mar 27;57(6):2429-39.
2. Thurmond RL, et al. J Pharmacol Exp Ther. 2014 May;349(2):176-84.
3. Kollmeier A, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7.
4. Murata Y, et al. J Dermatol. 2015 Feb;42(2):129-39.

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